diff --git a/python-setuptools.spec b/python-setuptools.spec
index 747d7ee..a2459b5 100644
--- a/python-setuptools.spec
+++ b/python-setuptools.spec
@@ -13,7 +13,7 @@
 
 Name:           python-setuptools
 # When updating, update the bundled libraries versions bellow!
-Version:        46.2.0
+Version:        46.4.0
 Release:        1%{?dist}
 Summary:        Easily build and distribute Python packages
 # setuptools is MIT
@@ -25,9 +25,6 @@ License:        MIT and (BSD or ASL 2.0)
 URL:            https://pypi.python.org/pypi/%{srcname}
 Source0:        %{pypi_source %{srcname} %{version} zip}
 
-# https://github.com/pypa/setuptools/issues/2100
-Patch1:         reuse-ack2to3-in-TestDevelop-test_2to3_user_mode.patch
-
 BuildArch:      noarch
 
 BuildRequires:  gcc
@@ -174,6 +171,10 @@ PYTHONDONTWRITEBYTECODE=1 PYTHONPATH=$(pwd) pytest-%{python3_version} \
 
 
 %changelog
+* Mon May 18 2020 Tomas Hrnciar <thrnciar@redhat.com> - 46.4.0-1
+- Update to 46.4.0 (#1835411)
+- https://setuptools.readthedocs.io/en/latest/history.html#v46-4-0
+
 * Tue May 12 2020 Tomas Hrnciar <thrnciar@redhat.com> - 46.2.0-1
 - Update to 46.2.0 (#1833826)
 - https://setuptools.readthedocs.io/en/latest/history.html#v46-2-0
diff --git a/reuse-ack2to3-in-TestDevelop-test_2to3_user_mode.patch b/reuse-ack2to3-in-TestDevelop-test_2to3_user_mode.patch
deleted file mode 100644
index 40eb1bf..0000000
--- a/reuse-ack2to3-in-TestDevelop-test_2to3_user_mode.patch
+++ /dev/null
@@ -1,61 +0,0 @@
-diff --git a/setuptools/tests/__init__.py b/setuptools/tests/__init__.py
-index 9c77b51..6377d78 100644
---- a/setuptools/tests/__init__.py
-+++ b/setuptools/tests/__init__.py
-@@ -6,7 +6,7 @@ from setuptools.extern.six import PY2, PY3
- 
- 
- __all__ = [
--    'fail_on_ascii', 'py2_only', 'py3_only'
-+    'fail_on_ascii', 'py2_only', 'py3_only', 'ack_2to3'
- ]
- 
- 
-@@ -16,3 +16,5 @@ fail_on_ascii = pytest.mark.xfail(is_ascii, reason="Test fails in this locale")
- 
- py2_only = pytest.mark.skipif(not PY2, reason="Test runs on Python 2 only")
- py3_only = pytest.mark.skipif(not PY3, reason="Test runs on Python 3 only")
-+
-+ack_2to3 = pytest.mark.filterwarnings('ignore:2to3 support is deprecated')
-diff --git a/setuptools/tests/test_develop.py b/setuptools/tests/test_develop.py
-index 792975f..403d52c 100644
---- a/setuptools/tests/test_develop.py
-+++ b/setuptools/tests/test_develop.py
-@@ -17,6 +17,7 @@ import pytest
- 
- from setuptools.command.develop import develop
- from setuptools.dist import Distribution
-+from setuptools.tests import ack_2to3
- from . import contexts
- from . import namespaces
- 
-@@ -65,6 +66,7 @@ class TestDevelop:
-     @pytest.mark.skipif(
-         in_virtualenv or in_venv,
-         reason="Cannot run when invoked in a virtualenv or venv")
-+    @ack_2to3
-     def test_2to3_user_mode(self, test_env):
-         settings = dict(
-             name='foo',
-diff --git a/setuptools/tests/test_test.py b/setuptools/tests/test_test.py
-index 0f77d8f..892fd12 100644
---- a/setuptools/tests/test_test.py
-+++ b/setuptools/tests/test_test.py
-@@ -10,6 +10,7 @@ import pytest
- 
- from setuptools.command.test import test
- from setuptools.dist import Distribution
-+from setuptools.tests import ack_2to3
- 
- from .textwrap import DALS
- 
-@@ -73,9 +74,6 @@ def quiet_log():
-     log.set_verbosity(0)
- 
- 
--ack_2to3 = pytest.mark.filterwarnings('ignore:2to3 support is deprecated')
--
--
- @pytest.mark.usefixtures('sample_test', 'quiet_log')
- @ack_2to3
- def test_test(capfd):
diff --git a/sources b/sources
index c105f0f..5f98d8c 100644
--- a/sources
+++ b/sources
@@ -1 +1 @@
-SHA512 (setuptools-46.2.0.zip) = d8d89a99c6a3be0a343d6a0e17117ba00393188d69c8995a5dbe9a7772c002fc301a53963288231e3f8053ffda4cafd5406edb2f4650f2036c665f8e3eb5822e
+SHA512 (setuptools-46.4.0.zip) = 31e58fd1d682089a45d23aa07c3c2c4c952ca016fa4c3416b2cba979d8b57369f80baef98ce857912e506e87d6cb456497a1ce1c75a0cdf1ee25d4e753b58726