diff --git a/setup.py b/setup.py
index 3eb6ad1..3437e48 100644
--- a/setup.py
+++ b/setup.py
@@ -1331,20 +1331,14 @@ class PyBuildExt(build_ext):
             exts.append( Extension('termios', ['termios.c']) )
             # Jeremy Hylton's rlimit interface
             exts.append( Extension('resource', ['resource.c']) )
+        else:
+            missing.extend(['resource', 'termios'])
 
-            # Sun yellow pages. Some systems have the functions in libc.
-            if (host_platform not in ['cygwin', 'qnx6'] and
-                find_file('rpcsvc/yp_prot.h', inc_dirs, []) is not None):
-                if (self.compiler.find_library_file(lib_dirs, 'nsl')):
-                    libs = ['nsl']
-                else:
-                    libs = []
-                exts.append( Extension('nis', ['nismodule.c'],
-                                       libraries = libs) )
-            else:
-                missing.append('nis')
+        nis = self._detect_nis(inc_dirs, lib_dirs)
+        if nis is not None:
+            exts.append(nis)
         else:
-            missing.extend(['nis', 'resource', 'termios'])
+            missing.append('nis')
 
         # Curses support, requiring the System V version of curses, often
         # provided by the ncurses library.
@@ -2179,6 +2173,51 @@ class PyBuildExt(build_ext):
         )
         return ext
 
+    def _detect_nis(self, inc_dirs, lib_dirs):
+        if host_platform in {'win32', 'cygwin', 'qnx6'}:
+            return None
+
+        libs = []
+        library_dirs = []
+        includes_dirs = []
+
+        # Latest glibc has moved Sun RPC headers into tircp and nsl sub
+        # directories. rpc code has been moved to libtirpc.
+        rpcsvc_inc = find_file(
+            'rpcsvc/yp_prot.h', inc_dirs,
+            ['/usr/local/include/nsl', '/usr/include/nsl']
+        )
+        rpc_inc = find_file(
+            'rpc/rpc.h', inc_dirs,
+            ['/usr/local/include/tirpc', '/usr/include/tirpc']
+        )
+        if rpcsvc_inc is None or rpc_inc is None:
+            # not found
+            return None
+        includes_dirs.extend(rpcsvc_inc)
+        includes_dirs.extend(rpc_inc)
+
+        if self.compiler.find_library_file(lib_dirs, 'nsl'):
+            libs.append('nsl')
+        else:
+            # libnsl-devel: check for libnsl in nsl/ subdirectory
+            nsl_dirs = [os.path.join(lib_dir, 'nsl') for lib_dir in lib_dirs]
+            libnsl = self.compiler.find_library_file(nsl_dirs, 'nsl')
+            if libnsl is not None:
+                library_dirs.append(os.path.dirname(libnsl))
+                libs.append('nsl')
+
+        if self.compiler.find_library_file(lib_dirs, 'tirpc'):
+            libs.append('tirpc')
+
+        return Extension(
+            'nis', ['nismodule.c'],
+            libraries=libs,
+            library_dirs=library_dirs,
+            include_dirs=includes_dirs
+        )
+
+
 class PyBuildInstall(install):
     # Suppress the warning about installation into the lib_dynload
     # directory, which is not in sys.path when running Python during