diff --git a/.gitignore b/.gitignore
index 1c93fed..1313339 100644
--- a/.gitignore
+++ b/.gitignore
@@ -22,3 +22,4 @@ IRanges_1.6.8.tar.gz
 /IRanges_2.8.1.tar.gz
 /IRanges_2.10.1.tar.gz
 /IRanges_2.12.0.tar.gz
+/IRanges_2.14.10.tar.gz
diff --git a/R-IRanges.spec b/R-IRanges.spec
index 52c2509..1525440 100644
--- a/R-IRanges.spec
+++ b/R-IRanges.spec
@@ -1,9 +1,9 @@
 %global packname  IRanges
-%global Rvers     3.4.0
+%global Rvers     3.5.0
 %global bootstrap 1
 
 Name:             R-%{packname}
-Version:          2.12.0
+Version:          2.14.10
 Release:          1%{dist}
 Summary:          Low-level containers for storing sets of integer ranges
 Group:            Applications/Engineering 
@@ -11,14 +11,14 @@ License:          Artistic 2.0 and Copyright only
 # See https://www.redhat.com/archives/fedora-r-devel-list/2009-April/msg00001.html
 URL:              http://bioconductor.org/packages/release/bioc/html/IRanges.html
 Source0:          http://bioconductor.org/packages/release/bioc/src/contrib/%{packname}_%{version}.tar.gz
-Requires:         R-core >= %{Rvers} R-RUnit R-methods R-stats R-utils R-stats4 R-BiocGenerics >= 0.23.3 R-S4Vectors >= 0.15.5
+Requires:         R-core >= %{Rvers} R-RUnit R-methods R-stats R-utils R-stats4 R-BiocGenerics >= 0.25.3 R-S4Vectors >= 0.18.2
 # We can't require R-GenomicRanges until it has been built (it deps on R-IRanges)
 %if %{bootstrap} < 1
 Requires:         R-GenomicRanges
 %endif
 BuildRequires:    R-devel >= %{Rvers} tex(latex)
-BuildRequires:    R-methods R-stats R-RUnit R-utils R-stats4 R-BiocGenerics >= 0.23.3
-BuildRequires:    R-S4Vectors-devel >= 0.15.5
+BuildRequires:    R-methods R-stats R-RUnit R-utils R-stats4 R-BiocGenerics >= 0.25.3
+BuildRequires:    R-S4Vectors-devel >= 0.18.2
 # R-GenomicRanges is only needed for check, but it makes a dep loop
 %if %{bootstrap} < 1
 BuildRequires:    R-GenomicRanges
@@ -85,6 +85,9 @@ rm -rf %{buildroot}%{_libdir}/R/library/R.css
 %{_libdir}/R/library/%{packname}/include
 
 %changelog
+* Wed May 16 2018 Tom Callaway <spot@fedoraproject.org> - 2.14.10-1
+- update to 2.14.10, rebuild for R 3.5.0
+
 * Wed Mar 14 2018 Tom Callaway <spot@fedoraproject.org> - 2.12.0-1
 - update to 2.12.0
 
diff --git a/sources b/sources
index c89a9d5..27def55 100644
--- a/sources
+++ b/sources
@@ -1 +1 @@
-SHA512 (IRanges_2.12.0.tar.gz) = bc0e23f15c88cb1672de4946530baa81c69dec28e829438ce4ad1e488e41808c77a82456fa612eee92444db356465adb7e511457cf21311af7f1545c2f1ceab5
+SHA512 (IRanges_2.14.10.tar.gz) = eccbd08e3403840621d314cee747275c6d1b2992da89faf0bcecd7e3fb630115895fbfa677a14c40442e34513d76c0cd73299114398931d5321871d21da83e91