diff --git a/avogadro2-libs.spec b/avogadro2-libs.spec
index a9d40ba..804d818 100644
--- a/avogadro2-libs.spec
+++ b/avogadro2-libs.spec
@@ -12,7 +12,7 @@
 
 Name:           avogadro2-libs
 Version:        1.96.0
-Release:        2%{?dist}
+Release:        3%{?dist}
 Summary:        Avogadro2 libraries
 
 # BSD is main license
@@ -36,9 +36,6 @@ Patch1: %{name}-1.94.0-do_not_download_external_files.patch
 
 BuildRequires:  boost-devel
 BuildRequires:  python%{python3_pkgversion}-devel
-%if 0%{?fedora}
-BuildRequires:  boost-python3-devel
-%endif
 %if 0%{?rhel}
 BuildRequires:  epel-rpm-macros
 %endif
@@ -197,6 +194,9 @@ rm -rf %{buildroot}%{_datadir}/doc
 %license LICENSE
 
 %changelog
+* Fri Jun 24 2022 Jonathan Wakely <jwakely@redhat.com> - 1.96.0-3
+- Remove obsolete boost-python3-devel build dependency (#2100748)
+
 * Mon Jun 13 2022 Python Maint <python-maint@redhat.com> - 1.96.0-2
 - Rebuilt for Python 3.11