diff --git a/bwa-simde.patch b/bwa-simde.patch
new file mode 100644
index 0000000..6be4d66
--- /dev/null
+++ b/bwa-simde.patch
@@ -0,0 +1,16 @@
+diff --git a/ksw.c b/ksw.c
+index 9793e5eb..76f39c98 100644
+--- a/ksw.c
++++ b/ksw.c
+@@ -26,7 +26,11 @@
+ #include <stdlib.h>
+ #include <stdint.h>
+ #include <assert.h>
++#ifdef USE_SIMDE
++#include <simde/x86/sse2.h>
++#else
+ #include <emmintrin.h>
++#endif
+ #include "ksw.h"
+ 
+ #ifdef USE_MALLOC_WRAPPERS
diff --git a/bwa.spec b/bwa.spec
index 55626e9..4d0fce3 100644
--- a/bwa.spec
+++ b/bwa.spec
@@ -1,6 +1,6 @@
 Name:           bwa
 Version:        0.7.17
-Release:        1%{?dist}
+Release:        2%{?dist}
 Summary:        Burrows-Wheeler Alignment tool
 
 License:        GPLv3
@@ -9,11 +9,14 @@ Source0:        http://downloads.sourceforge.net/bio-%{name}/%{name}-%{version}.
 # Fix building against GCC 10.
 # https://github.com/lh3/bwa/commit/2a1ae7b6f34a96ea25be007ac9d91e57e9d32284
 Patch0:         bwa-fix-build-gcc10.patch
-# 0.7.x versions only build on x86_64
-ExclusiveArch:  x86_64
-
+# Enable non-x86_64 CPU architectures with simde.
+# https://github.com/lh3/bwa/pull/283
+Patch1:         bwa-simde.patch
 BuildRequires:  gcc
 BuildRequires:  perl-generators
+%ifnarch x86_64
+BuildRequires:  simde-devel
+%endif
 BuildRequires:  zlib-devel
 
 %description
@@ -25,10 +28,19 @@ for read shorter than 150bp and the other for longer reads.
 %prep
 %setup -q
 %patch0 -p1
+%patch1 -p1
 
 
 %build
-make %{?_smp_mflags} CFLAGS="%{optflags}"
+# Set -O3 for the better performance.
+# https://github.com/lh3/bwa/pull/278
+CFLAGS="%{optflags} -O3"
+%ifnarch x86_64
+# See Makefile in the pull request.
+# https://github.com/lh3/bwa/pull/283
+CFLAGS="${CFLAGS} -DUSE_SIMDE -DSIMDE_ENABLE_NATIVE_ALIASES -fopenmp-simd -DSIMDE_ENABLE_OPENMP"
+%endif
+make %{?_smp_mflags} CFLAGS="${CFLAGS}"
 
 
 %install
@@ -58,6 +70,10 @@ install -m 0644 bwa.1 %{buildroot}/%{_mandir}/man1/bwa.1
 
 
 %changelog
+* Fri May 22 2020 Jun Aruga <jaruga@redhat.com> - 0.7.17-2
+- Enable non-x86_64 CPU architectures with simde.
+- Set -O3 for the better performance.
+
 * Thu Apr 16 2020 Jun Aruga <jaruga@redhat.com> - 0.7.17-1
 - Update to upstream release 0.7.17
 - Move bwakit files to data directory to avoid conflicts.