diff --git a/0000_CMake_FindPython3_13.patch b/0000_CMake_FindPython3_13.patch
new file mode 100644
index 0000000..53782b6
--- /dev/null
+++ b/0000_CMake_FindPython3_13.patch
@@ -0,0 +1,21 @@
+diff --git a/cmake/modules/FindPythonEasy.cmake b/cmake/modules/FindPythonEasy.cmake
+index 0e13c0a..b829e94 100644
+--- a/cmake/modules/FindPythonEasy.cmake
++++ b/cmake/modules/FindPythonEasy.cmake
+@@ -15,7 +15,7 @@
+ LIST(APPEND L_PYTHON_VERSIONS
+     "1.5" "1.6"
+     "2.0" "2.1" "2.2" "2.4" "2.5" "2.6" "2.7" "2.8"
+-    "3" "3.0" "3.1" "3.2" "3.3" "3.4" "3.5" "3.6" "3.7" "3.8" "3.9" "3.10" "3.11" "3.12"
++    "3" "3.0" "3.1" "3.2" "3.3" "3.4" "3.5" "3.6" "3.7" "3.8" "3.9" "3.10" "3.11" "3.12" "3.13"
+ )
+ 
+ INCLUDE(FindPackageHandleStandardArgs)
+@@ -28,6 +28,7 @@ INCLUDE(FindPackageHandleStandardArgs)
+   HINTS
+   ${ALT_PYTHON_LOCATION}/bin
+   PATHS
++  [HKEY_LOCAL_MACHINE\\SOFTWARE\\Python\\PythonCore\\3.13\\InstallPath]
+   [HKEY_LOCAL_MACHINE\\SOFTWARE\\Python\\PythonCore\\3.12\\InstallPath]
+   [HKEY_LOCAL_MACHINE\\SOFTWARE\\Python\\PythonCore\\3.11\\InstallPath]
+   [HKEY_LOCAL_MACHINE\\SOFTWARE\\Python\\PythonCore\\3.10\\InstallPath]
diff --git a/gfal2-python.spec b/gfal2-python.spec
index f5ab524..a198491 100644
--- a/gfal2-python.spec
+++ b/gfal2-python.spec
@@ -39,7 +39,7 @@
 
 Name:               gfal2-python
 Version:            1.12.1
-Release:            1%{?dist}
+Release:            2%{?dist}
 Summary:            Python bindings for gfal 2
 License:            ASL 2.0
 URL:                http://dmc.web.cern.ch/
@@ -49,6 +49,7 @@ URL:                http://dmc.web.cern.ch/
 # popd
 # tar czf gfal2-python-1.12.1.tar.gz --exclude-vcs gfal2-python-1.12.1
 Source0:            %{name}-%{version}.tar.gz
+Patch0:             0000_CMake_FindPython3_13.patch
 
 BuildRequires:      gcc-c++
 BuildRequires:      cmake3
@@ -121,6 +122,7 @@ Documentation files for %{name}.
 
 %prep
 %setup -q
+%patch0 -p1
 
 %build
 # Make sure the version in the spec file and the version used
@@ -177,6 +179,9 @@ fi
 %endif
 
 %changelog
+* Tue Nov 21 2023 Mihai Patrascoiu <mihai.patrascoiu@cern.ch> - 1.12.1-2
+- Patch for the Python 3.13 rebuild (close RHBZ#2250873)
+
 * Tue Sep 05 2023 Mihai Patrascoiu <mihai.patrascoiu@cern.ch> - 1.12.1-1
 - Upgrade to upstream release 1.12.1
 - Closes bugzilla#2154855, bugzilla#2220000, bugzilla#2225821