diff -rupN Python-2.7.14/Lib/ctypes/__init__.py Python-2.7.14-new/Lib/ctypes/__init__.py --- Python-2.7.14/Lib/ctypes/__init__.py 2017-09-16 19:38:35.000000000 +0200 +++ Python-2.7.14-new/Lib/ctypes/__init__.py 2017-10-31 18:36:42.713180467 +0100 @@ -446,7 +446,9 @@ class LibraryLoader(object): cdll = LibraryLoader(CDLL) pydll = LibraryLoader(PyDLL) -if _os.name in ("nt", "ce"): +if _os.name == "nt" and _sys.version.find('GCC') >= 0: + pythonapi = PyDLL("libpython%d.%d.dll" % _sys.version_info[:2], None) +elif _os.name in ("nt", "ce"): pythonapi = PyDLL("python dll", None, _sys.dllhandle) elif _sys.platform == "cygwin": pythonapi = PyDLL("libpython%d.%d.dll" % _sys.version_info[:2])