diff --git a/Inline-Python-0.56-Use-python3.patch b/Inline-Python-0.56-Use-python3.patch
deleted file mode 100644
index bc16e6a..0000000
--- a/Inline-Python-0.56-Use-python3.patch
+++ /dev/null
@@ -1,12 +0,0 @@
-diff -up Inline-Python-0.56/Makefile.PL.orig Inline-Python-0.56/Makefile.PL
---- Inline-Python-0.56/Makefile.PL.orig	2018-07-09 12:54:47.605495856 +0200
-+++ Inline-Python-0.56/Makefile.PL	2018-07-09 12:55:15.919418183 +0200
-@@ -22,7 +22,7 @@ unless ($sel) {
-     my $sep = $^O eq 'MSWin32' ? ";" : ":";
-     for $p (split /$sep/, $ENV{PATH}) {
-         $p =~ s/^~/$ENV{HOME}/;
--        $p .= "/python";
-+        $p .= "/python3";
-         next unless -f $p and -x $p;
-         next if $pythons{abs_path($p)}++; # filter symlinked duplicates
-         push @pythons, { path => $p };
diff --git a/perl-Inline-Python-pyinit.patch b/perl-Inline-Python-pyinit.patch
new file mode 100644
index 0000000..300f34e
--- /dev/null
+++ b/perl-Inline-Python-pyinit.patch
@@ -0,0 +1,47 @@
+From 90b68bdf370c07b1d3fdd46bbdf1b154ed74b91b Mon Sep 17 00:00:00 2001
+From: Mattias Ellert <mattias.ellert@physics.uu.se>
+Date: Wed, 18 Aug 2021 16:41:10 +0200
+Subject: [PATCH] Call Py_Initialize() before calling PyBytes_FromString()
+
+Not doing this gives a segmentation fault with Python 3.10
+---
+ Python.xs | 16 ++++++++--------
+ 1 file changed, 8 insertions(+), 8 deletions(-)
+
+diff --git a/Python.xs b/Python.xs
+index 11d5033..7a3c793 100644
+--- a/Python.xs
++++ b/Python.xs
+@@ -25,14 +25,6 @@ void do_pyinit() {
+ #ifdef EXPOSE_PERL
+     PyObject *main_dict;
+     PyObject *perl_obj;
+-
+-#if PY_MAJOR_VERSION >= 3
+-    PyObject *dummy1 = PyBytes_FromString(""),
+-             *dummy2 = PyBytes_FromString("main");
+-#else
+-    PyObject *dummy1 = PyString_FromString(""),
+-             *dummy2 = PyString_FromString("main");
+-#endif
+ #endif
+     /* sometimes Python needs to know about argc and argv to be happy */
+     int _python_argc = 1;
+@@ -48,6 +40,14 @@ void do_pyinit() {
+     PySys_SetArgv(_python_argc, _python_argv);  /* Tk needs this */
+ 
+ #ifdef EXPOSE_PERL
++#if PY_MAJOR_VERSION >= 3
++    PyObject *dummy1 = PyBytes_FromString(""),
++             *dummy2 = PyBytes_FromString("main");
++#else
++    PyObject *dummy1 = PyString_FromString(""),
++             *dummy2 = PyString_FromString("main");
++#endif
++
+     /* create the perl module and add functions */
+     initperl();
+ 
+-- 
+2.31.1
+
diff --git a/perl-Inline-Python.spec b/perl-Inline-Python.spec
index ef7899b..2f820d0 100644
--- a/perl-Inline-Python.spec
+++ b/perl-Inline-Python.spec
@@ -1,11 +1,14 @@
 Name:           perl-Inline-Python
 Version:        0.56
-Release:        18%{?dist}
+Release:        19%{?dist}
 Summary:        Write Perl subs and classes in Python
 License:        GPL+ or Artistic
 URL:            https://metacpan.org/release/Inline-Python
 Source0:        https://cpan.metacpan.org/authors/id/N/NI/NINE/Inline-Python-%{version}.tar.gz
-Patch0:         Inline-Python-0.56-Use-python3.patch
+#               Call Py_Initialize() before calling PyBytes_FromString()
+#               Fixes segmentation fault with python 3.10
+#               https://github.com/niner/inline-python-pm/pull/33
+Patch0:         %{name}-pyinit.patch
 BuildRequires:  gcc
 BuildRequires:  findutils
 BuildRequires:  make
@@ -59,7 +62,7 @@ name-space is cached, and subsequent calls use the cached version.
 %patch0 -p1
 
 %build
-%{__perl} Makefile.PL INSTALLDIRS=vendor OPTIMIZE="$RPM_OPT_FLAGS" NO_PACKLIST=1
+INLINE_PYTHON_EXECUTABLE=/usr/bin/python3 %{__perl} Makefile.PL INSTALLDIRS=vendor OPTIMIZE="$RPM_OPT_FLAGS" NO_PACKLIST=1
 make %{?_smp_mflags}
 
 %install
@@ -79,6 +82,9 @@ make test
 %{_mandir}/man3/*
 
 %changelog
+* Thu Aug 19 2021 Mattias Ellert <mattias.ellert@physics.uu.se> - 0.56-19
+- Fix segmentation fault with python 3.10
+
 * Thu Jul 22 2021 Fedora Release Engineering <releng@fedoraproject.org> - 0.56-18
 - Rebuilt for https://fedoraproject.org/wiki/Fedora_35_Mass_Rebuild