diff --git a/.cvsignore b/.cvsignore
index 47ebd88..fef7976 100644
--- a/.cvsignore
+++ b/.cvsignore
@@ -1 +1 @@
-biopython-1.52.tar.gz
+biopython-1.53.tar.gz
diff --git a/python-biopython.spec b/python-biopython.spec
index 4ddde7d..17dc4e4 100644
--- a/python-biopython.spec
+++ b/python-biopython.spec
@@ -2,7 +2,7 @@
 %{!?python_sitearch: %define python_sitearch %(%{__python} -c "from distutils.sysconfig import get_python_lib; print get_python_lib(1)")}
 
 Name:             python-biopython
-Version:          1.52
+Version:          1.53
 Release:          1%{?dist}
 Summary:          Python tools for computational molecular biology
 Source0:          http://biopython.org/DIST/biopython-%{version}.tar.gz
@@ -69,6 +69,9 @@ rm -rf $RPM_BUILD_ROOT
 %{python_sitearch}/BioSQL/*
 
 %changelog
+* Tue Dec 15 2009 Alex Lancaster <alexlan[AT]fedoraproject org> - 1.53-1
+- Update to upstream 1.53
+
 * Thu Oct 15 2009 Alex Lancaster <alexlan[AT]fedoraproject org> - 1.52-1
 - Update to latest upstream (1.52)
 
diff --git a/sources b/sources
index 350c398..a836359 100644
--- a/sources
+++ b/sources
@@ -1 +1 @@
-87e31749d431ed8a2d4fa909a42a478f  biopython-1.52.tar.gz
+df1004ec64b9b593c0e690c14a20667a  biopython-1.53.tar.gz