diff --git a/python-biopython.spec b/python-biopython.spec
index b27c30e..d47bf94 100644
--- a/python-biopython.spec
+++ b/python-biopython.spec
@@ -3,7 +3,7 @@
 
 Name:             python-biopython
 Version:          1.43
-Release:          3%{?dist}
+Release:          4%{?dist}
 Summary:          Python tools for computational molecular biology
 Source0:          http://biopython.org/DIST/biopython-%{version}.tar.gz
 Patch0:           biopython-setup_test.patch
@@ -22,6 +22,7 @@ Requires:         mx
 Requires:         python-numeric
 Requires:         MySQL-python
 Requires:         python-psycopg
+Requires:         wise2
 
 %description
 A set of freely available Python tools for computational molecular
@@ -72,6 +73,10 @@ rm -rf $RPM_BUILD_ROOT
 %{python_sitearch}/BioSQL/*
 
 %changelog
+* Mon Apr 25 2007 Alex Lancaster <alexl@users.sourceforge.net> 1.43-4
+- Add wise2 Requires since the Wise biopython module uses the
+  command-line behind-the-scenes.
+
 * Mon Apr 17 2007 Alex Lancaster <alexl@users.sourceforge.net> 1.43-3
 - Use python_sitearch macro to enable x86_64 builds work.