diff --git a/python-biopython.spec b/python-biopython.spec
index 1869f55..2eddb9f 100644
--- a/python-biopython.spec
+++ b/python-biopython.spec
@@ -3,7 +3,7 @@
 
 Name:             python-biopython
 Version:          1.48
-Release:          2%{?dist}
+Release:          3%{?dist}
 Summary:          Python tools for computational molecular biology
 Source0:          http://biopython.org/DIST/biopython-%{version}.tar.gz
 License:          MIT
@@ -15,12 +15,12 @@ BuildRequires:    python-reportlab
 BuildRequires:    mx
 BuildRequires:    python-numeric
 BuildRequires:    MySQL-python
-BuildRequires:    python-psycopg
+#BuildRequires:    python-psycopg
 Requires:         python-reportlab
 Requires:         mx
 Requires:         python-numeric
 Requires:         MySQL-python
-Requires:         python-psycopg
+#Requires:         python-psycopg
 Requires:         wise2
 
 %description
@@ -74,6 +74,10 @@ rm -rf $RPM_BUILD_ROOT
 %{python_sitearch}/BioSQL/*
 
 %changelog
+* Sun Nov 30 2008 Alex Lancaster <alexlan[AT]fedoraproject org> - 1.48-3
+- Temporarily disable python-psycopg dependency until it is rebuilt
+  for Python 2.6
+
 * Sat Nov 29 2008 Ignacio Vazquez-Abrams <ivazqueznet+rpm@gmail.com> - 1.48-2
 - Rebuild for Python 2.6