diff --git a/python-biopython.spec b/python-biopython.spec
index 97509a4..f9a7061 100644
--- a/python-biopython.spec
+++ b/python-biopython.spec
@@ -24,7 +24,7 @@
 
 Name:             python-%{pypi_name}
 Version:          1.77
-Release:          2%{?dist}
+Release:          3%{?dist}
 Summary:          Python tools for computational molecular biology
 Source0:          %{pypi_source}
 
@@ -95,6 +95,7 @@ Summary: Python3 tools for computational molecular biology
 %{?python_provide:%python_provide python%{python3_pkgversion}-%{module}}
 
 BuildRequires:    python%{python3_pkgversion}-devel
+BuildRequires:    python%{python3_pkgversion}-setuptools
 BuildRequires:    flex-devel
 BuildRequires:    python%{python3_pkgversion}-reportlab
 BuildRequires:    python%{python3_pkgversion}-numpy
@@ -313,6 +314,9 @@ popd
 %license %{module}-%{version}/LICENSE.rst
 
 %changelog
+* Wed Jun 24 2020 Antonio Trande <sagitter@fedoraproject.org> - 1.77-3
+- BuildRequires python3-setuptools explicitly
+
 * Fri May 29 2020 Antonio Trande <sagitter@fedoraproject.org> - 1.77-2
 - Rebuilt for Python 3.9
 - Remove obsolete Python3.9 patch