diff --git a/python-biopython.spec b/python-biopython.spec
index 42456fe..f3e5232 100644
--- a/python-biopython.spec
+++ b/python-biopython.spec
@@ -24,7 +24,7 @@
 
 Name:             python-%{pypi_name}
 Version:          1.78
-Release:          1%{?dist}
+Release:          2%{?dist}
 Summary:          Python tools for computational molecular biology
 Source0:          %{pypi_source}
 
@@ -237,6 +237,7 @@ popd
 pushd python2
 export PYTHONPATH=$RPM_BUILD_ROOT%{python2_sitearch}
 find . -name 'run_tests.py' | xargs pathfix.py -pn -i "%{__python2}"
+find . -name '__init__.py' | xargs rm -f
 for test in `ls test_*.py | grep -v Tutorial`; do
 %{__python2} run_tests.py --offline -v ${test}
 done
@@ -247,6 +248,7 @@ popd
 %if 0%{?with_python3}
 pushd python3/Tests
 find . -name 'run_tests.py' | xargs pathfix.py -pn -i "%{__python3}"
+find . -name '__init__.py' | xargs rm -f
 # See https://github.com/biopython/biopython/issues/2128; https://github.com/biopython/biopython/issues/2120
 # and https://bugs.python.org/issue24214
 %if 0%{?python3_version_nodots} == 38
@@ -265,6 +267,7 @@ popd
 %if 0%{?with_python3_other}
 pushd python%{python3_other_pkgversion}/Tests
 find . -name 'run_tests.py' | xargs pathfix.py -pn -i "%{__python3_other}"
+find . -name '__init__.py' | xargs rm -f
 for test in `ls test_*.py | grep -v Nexus | grep -v Phylo | grep -v Tutorial | grep -v bgzf`; do
 echo $LANG
 export PYTHONPATH=$RPM_BUILD_ROOT%{python3_other_sitearch}
@@ -314,6 +317,9 @@ popd
 %license %{module}-%{version}/LICENSE.rst
 
 %changelog
+* Fri Nov 27 2020 Antonio Trande <sagitter@fedoraproject.org> - 1.78-2
+- Remove __init__.py before testing
+
 * Fri Sep 04 2020 Antonio Trande <sagitter@fedoraproject.org> - 1.78-1
 - Release 1.78