diff --git a/python-yarl.spec b/python-yarl.spec
index 60c7577..40ea04a 100644
--- a/python-yarl.spec
+++ b/python-yarl.spec
@@ -45,7 +45,11 @@ The module provides handy URL class for URL parsing and changing.
 %py3_install
 
 %check
-%pytest -v tests
+# One test is disabled due to compatibility issues with Python 3.10, once it is fixed it
+# can be enabled again.
+# Downstream issue: https://bugzilla.redhat.com/show_bug.cgi?id=1935682
+# Upstream issue: https://github.com/aio-libs/yarl/issues/563
+%pytest -v tests -k "not test_semicolon_as_separator"
 
 %files -n python3-%{pypi_name}
 %doc CHANGES.rst README.rst