diff -up src/sage/env.py.orig src/sage/env.py
--- src/sage/env.py.orig	2020-10-30 16:10:20.089999891 -0600
+++ src/sage/env.py	2020-10-31 12:11:19.256615196 -0600
@@ -391,7 +391,7 @@ def cython_aliases():
     aliases = {}
 
     for lib in ['fflas-ffpack', 'givaro', 'gsl', 'linbox', 'Singular',
-                'libpng', 'gdlib', 'm4ri', 'zlib', 'cblas', 'lapack']:
+                'libpng', 'gdlib', 'm4ri', 'zlib', 'openblas']:
         var = lib.upper().replace("-", "") + "_"
         if lib == 'zlib':
             aliases[var + "CFLAGS"] = ""
diff -up src/sage/matrix/matrix_integer_dense.pyx.orig src/sage/matrix/matrix_integer_dense.pyx
--- src/sage/matrix/matrix_integer_dense.pyx.orig	2020-10-30 11:52:49.737274785 -0600
+++ src/sage/matrix/matrix_integer_dense.pyx	2020-10-31 17:58:56.243063508 -0600
@@ -1,8 +1,8 @@
 # -*- coding: utf-8 -*-
 # distutils: extra_compile_args = M4RI_CFLAGS
-# distutils: libraries = iml ntl gmp m CBLAS_LIBRARIES
-# distutils: library_dirs = CBLAS_LIBDIR
-# distutils: include_dirs = M4RI_INCDIR CBLAS_INCDIR
+# distutils: libraries = iml ntl gmp m OPENBLAS_LIBRARIES
+# distutils: library_dirs = OPENBLAS_LIBDIR
+# distutils: include_dirs = M4RI_INCDIR OPENBLAS_INCDIR
 """
 Dense matrices over the integer ring
 
diff -up src/sage/matrix/matrix_modn_dense_double.pyx.orig src/sage/matrix/matrix_modn_dense_double.pyx
--- src/sage/matrix/matrix_modn_dense_double.pyx.orig	2020-10-24 11:37:59.000000000 -0600
+++ src/sage/matrix/matrix_modn_dense_double.pyx	2020-11-05 15:54:31.940411433 -0700
@@ -1,7 +1,7 @@
 # distutils: language = c++
-# distutils: libraries = CBLAS_LIBRARIES
-# distutils: library_dirs = CBLAS_LIBDIR
-# distutils: include_dirs = CBLAS_INCDIR
+# distutils: libraries = OPENBLAS_LIBRARIES
+# distutils: library_dirs = OPENBLAS_LIBDIR
+# distutils: include_dirs = OPENBLAS_INCDIR
 # distutils: extra_compile_args = -D_XPG6
 """
 Dense matrices over `\ZZ/n\ZZ` for `n < 2^{23}` using LinBox's ``Modular<double>``
diff -up src/sage/matrix/matrix_modn_dense_float.pyx.orig src/sage/matrix/matrix_modn_dense_float.pyx
--- src/sage/matrix/matrix_modn_dense_float.pyx.orig	2020-11-05 15:54:31.940411433 -0700
+++ src/sage/matrix/matrix_modn_dense_float.pyx	2020-11-05 15:55:38.853405001 -0700
@@ -1,7 +1,7 @@
 # distutils: language = c++
-# distutils: libraries = CBLAS_LIBRARIES
-# distutils: library_dirs = CBLAS_LIBDIR
-# distutils: include_dirs = CBLAS_INCDIR
+# distutils: libraries = OPENBLAS_LIBRARIES
+# distutils: library_dirs = OPENBLAS_LIBDIR
+# distutils: include_dirs = OPENBLAS_INCDIR
 """
 Dense matrices over `\ZZ/n\ZZ` for `n < 2^{11}` using LinBox's ``Modular<float>``
 
diff -up src/sage/matrix/matrix_rational_dense.pyx.orig src/sage/matrix/matrix_rational_dense.pyx
--- src/sage/matrix/matrix_rational_dense.pyx.orig	2020-10-30 11:34:26.031980257 -0600
+++ src/sage/matrix/matrix_rational_dense.pyx	2020-10-31 17:58:10.490106273 -0600
@@ -1,7 +1,7 @@
 # distutils: extra_compile_args = -D_XPG6 M4RI_CFLAGS
-# distutils: libraries = iml ntl m CBLAS_LIBRARIES
-# distutils: library_dirs = CBLAS_LIBDIR
-# distutils: include_dirs = M4RI_INCDIR CBLAS_INCDIR
+# distutils: libraries = iml ntl m OPENBLAS_LIBRARIES
+# distutils: library_dirs = OPENBLAS_LIBDIR
+# distutils: include_dirs = M4RI_INCDIR OPENBLAS_INCDIR
 
 """
 Dense matrices over the rational field
diff -up src/sage/misc/cython.py.orig src/sage/misc/cython.py
--- src/sage/misc/cython.py.orig	2020-10-30 16:08:06.039158996 -0600
+++ src/sage/misc/cython.py	2020-10-30 16:24:09.037024792 -0600
@@ -35,10 +35,9 @@ from sage.cpython.string import str_to_b
 
 
 # CBLAS can be one of multiple implementations
-cblas_pc = pkgconfig.parse('cblas')
-cblas_libs = list(cblas_pc['libraries'])
-cblas_library_dirs = list(cblas_pc['library_dirs'])
-cblas_include_dirs = list(cblas_pc['include_dirs'])
+cblas_libs = ['openblas']
+cblas_library_dirs = ['/usr/lib']
+cblas_include_dirs = ['/usr/include/openblas']
 
 standard_libs = [
     'mpfr', 'gmp', 'gmpxx', 'pari', 'm',
diff -up src/sage_setup/library_order.py.orig src/sage_setup/library_order.py
--- src/sage_setup/library_order.py.orig	2020-10-24 11:37:59.000000000 -0600
+++ src/sage_setup/library_order.py	2020-10-31 12:11:54.313540360 -0600
@@ -10,20 +10,18 @@ import os
 import pkgconfig
 
 # CBLAS can be one of multiple implementations
-cblas_pc = pkgconfig.parse('cblas')
-cblas_libs = cblas_pc['libraries']
-cblas_library_dirs = cblas_pc['library_dirs']
-cblas_include_dirs = cblas_pc['include_dirs']
+cblas_libs = ['openblas']
+cblas_library_dirs = ['/usr/lib']
+cblas_include_dirs = ['/usr/include/openblas']
 
 # TODO: Remove Cygwin hack by installing a suitable cblas.pc
 if os.path.exists('/usr/lib/libblas.dll.a'):
     cblas_libs = ['gslcblas']
 
 # LAPACK can be one of multiple implementations
-lapack_pc = pkgconfig.parse('lapack')
-lapack_libs = lapack_pc['libraries']
-lapack_library_dirs = lapack_pc['library_dirs']
-lapack_include_dirs = lapack_pc['include_dirs']
+lapack_libs = ['openblas']
+lapack_library_dirs = ['/usr/lib']
+lapack_include_dirs = ['/usr/include/openblas']
 
 # GD image library
 gd_pc = pkgconfig.parse('gdlib')