--- ugene-40.1/src/plugins_3rdparty/hmm2/src/u_search/HMMSearchDialogController.cpp.sse	2021-10-11 15:41:23.000000000 +0900
+++ ugene-40.1/src/plugins_3rdparty/hmm2/src/u_search/HMMSearchDialogController.cpp	2021-11-09 01:34:30.052988784 +0900
@@ -81,7 +81,9 @@
     QWidget* w = createController->getWidget();
     QVBoxLayout* l = qobject_cast<QVBoxLayout*>(layout());
     l->insertWidget(1, w);
+#if defined (__SSE2__)
     algoCombo->addItem(tr("SSE optimized"), HMMSearchAlgo_SSEOptimized);
+#endif
     algoCombo->addItem(tr("Conservative"), HMMSearchAlgo_Conservative);
 
     okButton = buttonBox->button(QDialogButtonBox::Ok);
--- ugene-40.1/src/plugins_3rdparty/hmm2/src/u_search/uhmmsearch.cpp.sse	2021-10-11 15:41:23.000000000 +0900
+++ ugene-40.1/src/plugins_3rdparty/hmm2/src/u_search/uhmmsearch.cpp	2021-11-09 01:34:30.052988784 +0900
@@ -56,9 +56,15 @@
     tophit_s* dhit = AllocTophits(200);  // domain hits:  200=lumpsize
 
     int nseq = 0;  // number of sequences searched
+#if defined(__SSE2__)
     if (s.alg == HMMSearchAlgo_SSEOptimized) {
         main_loop_opt(hmm, seq, seqLen, &thresh, do_forward, do_null2, do_xnu, histogram, ghit, dhit, &nseq, si, sseScoring);
-    } else if (s.alg == HMMSearchAlgo_Conservative) {
+    }
+#else
+    if (0) {
+    } 
+#endif
+      else if (s.alg == HMMSearchAlgo_Conservative) {
         main_loop_serial(hmm, seq, seqLen, &thresh, do_forward, do_null2, do_xnu, histogram, ghit, dhit, &nseq, si);
     } else {
         assert(false && "bad hmmsearch algorithm selected");
--- ugene-42.0/src/plugins_3rdparty/hmm2/src/u_search/uhmmsearch_sse.cpp.sse	2022-03-09 15:37:14.586340751 +0900
+++ ugene-42.0/src/plugins_3rdparty/hmm2/src/u_search/uhmmsearch_sse.cpp	2022-03-09 15:47:23.559077800 +0900
@@ -1,4 +1,5 @@
 #include <assert.h>
+#if defined (__SSE2__)
 #include <emmintrin.h>
 #include <hmmer2/funcs.h>
 
@@ -488,3 +489,4 @@ QList<float> sseScoring(unsigned char* d
 
     return results;
 }
+#endif
--- ugene-40.1/src/plugins_3rdparty/hmm2/src/u_search/uhmmsearch_sse.h.sse	2021-10-11 15:41:23.000000000 +0900
+++ ugene-40.1/src/plugins_3rdparty/hmm2/src/u_search/uhmmsearch_sse.h	2021-11-09 01:34:30.052988784 +0900
@@ -1,6 +1,8 @@
 #ifndef __HMMSEARCH_SSE_H__
 #define __HMMSEARCH_SSE_H__
 
+#if defined(__SSE2__)
 QList<float> sseScoring(unsigned char* dsq, int seqlen, plan7_s* hmm, HMMSeqGranulation* gr, U2::TaskStateInfo& ti);
+#endif
 
 #endif  // __HMMSEARCH_SSE_H__