diff --git a/uwsgi.spec b/uwsgi.spec
index 015fd25..3db1e53 100644
--- a/uwsgi.spec
+++ b/uwsgi.spec
@@ -135,7 +135,7 @@
 
 Name:           uwsgi
 Version:        2.0.20
-Release:        2.1%{?dist}
+Release:        3%{?dist}
 Summary:        Fast, self-healing, application container server
 # uwsgi is licensed under GPLv2 with a linking exception
 # docs are licensed under MIT
@@ -163,6 +163,7 @@ Patch12:        uwsgi_fix_php8.patch
 Patch13:        uwsgi_fix_chroot_chdir.patch
 # https://github.com/unbit/uwsgi/issues/2356
 Patch14:        uwsgi_fix_php_arginfo.patch
+Patch15:        uwsgi_fix_python_py_ssize_t.patch
 
 BuildRequires:  curl, libxml2-devel, libuuid-devel, jansson-devel
 BuildRequires:  libyaml-devel, ruby-devel
@@ -1170,6 +1171,7 @@ cp -p %{SOURCE5} README.Fedora
 %patch12 -p1
 %patch13 -p1
 %patch14 -p1
+%patch15 -p1
 
 %if %{with perl} && (%{with python3} || %{with python3_other})
 %{__python} -m lib2to3 --write --nobackups plugins/coroae/uwsgiplugin.py
@@ -1773,6 +1775,9 @@ exit 0
 
 
 %changelog
+* Sat Feb 19 2022 Ralf Ertzinger <ralf@skytale.net> - 2.0.20-3
+- Fix errors in uwsgi python module when building against python3.10 or higher
+
 * Wed Feb 16 2022 Ralf Ertzinger <ralf@skytale.net> - 2.0.20-2.1
 - F37 rebuild for new libgo
 
diff --git a/uwsgi_fix_python_py_ssize_t.patch b/uwsgi_fix_python_py_ssize_t.patch
new file mode 100644
index 0000000..ec90175
--- /dev/null
+++ b/uwsgi_fix_python_py_ssize_t.patch
@@ -0,0 +1,11 @@
+diff -uNr a/plugins/python/uwsgi_python.h b/plugins/python/uwsgi_python.h
+--- a/plugins/python/uwsgi_python.h	2021-10-06 07:22:45.000000000 +0200
++++ b/plugins/python/uwsgi_python.h	2022-02-19 18:39:10.929895062 +0100
+@@ -1,3 +1,7 @@
++// This needs to be defined before Python.h is included
++// to indicate that the code uses Py_ssize_t properly
++#define PY_SSIZE_T_CLEAN
++
+ #include <uwsgi.h>
+ #include <Python.h>
+