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Wine directory structure used in Fedora Linux:
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==============================================
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${HOME}/.wine/drive_c is the root directory (aka C: drive) wine looks for it 
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by default. It is created with (empty) C:\windows and C:\windows\system
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directories, needed to operate Wine without an existing Windows
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installation, if it does not already exist.
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If you want to use Wine with an existing Windows installation that is
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mounted, for example, in /mnt/windows-c, change the symlink
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${HOME}/.wine/dosdevices/c: to point to /mnt/windows-c instead of the
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defaults set by installation.
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If you do this, you can safely remove ${HOME}/.wine/drive_c.
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(Alternatively, just mount your Windows partition to ${HOME}/.wine/drive_c.)
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Wine bugs:
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==========
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If you find a bug, please take the time to move your ${HOME}/.wine directory
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someplace and try with a fresh version (like mv ${HOME}/.wine{,-save}). If the
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bug is still there look trough https://bugzilla.redhat.com and see if the bug
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is already reported. In case it is not please report it.