Fedora setuptools don't have option --install-layout=deb
--- ./lib/Debian/Debhelper/Buildsystem/python_distutils.pm.orig	2017-12-02 08:46:03.000000000 +0000
+++ ./lib/Debian/Debhelper/Buildsystem/python_distutils.pm	2018-01-07 23:43:53.492047778 +0000
@@ -166,7 +166,7 @@ sub setup_py {
 			         and $python_default =~ /^python2\.[2345]$/)
 			      or $python =~ /^python2\.[2345](?:-dbg)?$/ )) {
 				$this->doit_in_sourcedir($python, "setup.py",
-						$act, @_, "--install-layout=deb");
+						$act, @_);
 			}
 			else {
 				$this->doit_in_sourcedir($python, "setup.py",