diff --git a/MdePkg/Include/Base.h b/MdePkg/Include/Base.h
index 2da08b0c78..072eefdb94 100644
--- a/MdePkg/Include/Base.h
+++ b/MdePkg/Include/Base.h
@@ -318,7 +318,11 @@ struct _LIST_ENTRY {
 ///
 /// NULL pointer (VOID *)
 ///
+#ifndef OS_BUILD
+#ifndef UNIT_TEST_UEFI_BUILD
 #define NULL  ((VOID *) 0)
+#endif
+#endif
 
 //
 // Null character
@@ -810,6 +814,8 @@ typedef UINTN  *BASE_LIST;
 // Section 2.3.1 of the UEFI 2.3 Specification.
 //
 
+#ifndef OS_BUILD
+#ifndef UNIT_TEST_UEFI_BUILD
 STATIC_ASSERT (sizeof (BOOLEAN) == 1, "sizeof (BOOLEAN) does not meet UEFI Specification Data Type requirements");
 STATIC_ASSERT (sizeof (INT8)    == 1, "sizeof (INT8) does not meet UEFI Specification Data Type requirements");
 STATIC_ASSERT (sizeof (UINT8)   == 1, "sizeof (UINT8) does not meet UEFI Specification Data Type requirements");
@@ -823,6 +829,8 @@ STATIC_ASSERT (sizeof (CHAR8)   == 1, "sizeof (CHAR8) does not meet UEFI Specifi
 STATIC_ASSERT (sizeof (CHAR16)  == 2, "sizeof (CHAR16) does not meet UEFI Specification Data Type requirements");
 STATIC_ASSERT (sizeof (L'A')    == 2, "sizeof (L'A') does not meet UEFI Specification Data Type requirements");
 STATIC_ASSERT (sizeof (L"A")    == 4, "sizeof (L\"A\") does not meet UEFI Specification Data Type requirements");
+#endif
+#endif
 
 //
 // The following three enum types are used to verify that the compiler
@@ -843,9 +851,13 @@ typedef enum {
   __VerifyUint32EnumValue = 0xffffffff
 } __VERIFY_UINT32_ENUM_SIZE;
 
+#ifndef OS_BUILD
+#ifndef UNIT_TEST_UEFI_BUILD
 STATIC_ASSERT (sizeof (__VERIFY_UINT8_ENUM_SIZE) == 4, "Size of enum does not meet UEFI Specification Data Type requirements");
 STATIC_ASSERT (sizeof (__VERIFY_UINT16_ENUM_SIZE) == 4, "Size of enum does not meet UEFI Specification Data Type requirements");
 STATIC_ASSERT (sizeof (__VERIFY_UINT32_ENUM_SIZE) == 4, "Size of enum does not meet UEFI Specification Data Type requirements");
+#endif
+#endif
 
 /**
   Macro that returns a pointer to the data structure that contains a specified field of
-- 
2.22.0.windows.1