diff -rupN Python-2.7.13/configure.ac Python-2.7.13-new/configure.ac
--- Python-2.7.13/configure.ac	2017-01-21 01:46:12.331545364 +0100
+++ Python-2.7.13-new/configure.ac	2017-01-21 01:46:12.614542343 +0100
@@ -33,7 +33,12 @@ if test "$cross_compiling" = yes; then
 	    AC_MSG_ERROR([python$PACKAGE_VERSION interpreter not found])
 	fi
         AC_MSG_RESULT($interp)
-	PYTHON_FOR_BUILD='_PYTHON_PROJECT_BASE=$(abs_builddir) _PYTHON_HOST_PLATFORM=$(_PYTHON_HOST_PLATFORM) PYTHONPATH=$(shell test -f pybuilddir.txt && echo $(abs_builddir)/`cat pybuilddir.txt`:)$(srcdir)/Lib:$(srcdir)/Lib/$(PLATDIR) '$interp
+	# For reference see: http://bugs.python.org/msg180577
+	# interp's DESTSHARED must appear before that contained in pybuilddir.txt as otherwise, when compiling during make install,
+	# the build Python will attempt to load shared modules from the host Python, which will fail due to them being of the wrong
+	# architecture (e.g. x86_64 vs x86 or arm). It would probably be better if _sysconfigdata.py was placed elsewhere,
+	# i.e. in a folder that does not also contain incompatible shared modules.
+	PYTHON_FOR_BUILD='_PYTHON_PROJECT_BASE=$(abs_builddir) _PYTHON_HOST_PLATFORM=$(_PYTHON_HOST_PLATFORM) PYTHONPATH='$($interp -c "import sysconfig; print sysconfig.get_config_var(\"DESTSHARED\")")':$(shell test -f pybuilddir.txt && echo $(abs_builddir)/`cat pybuilddir.txt`:)$(srcdir)/Lib:$(srcdir)/Lib/$(PLATDIR) '$interp
     fi
     # Used to comment out stuff for rebuilding generated files
     GENERATED_COMMENT='#'